Univercells Technologies

Intensified extracellular vesicle production in fixed-bed bioreactors

Discover low-footprint, automated solutions for low-cost extracellular vesicles manufacturing

Case study

Expansion and harvest of fish stem cells using the scale-X™ bioreactor

A promising alternative for scaled up production of cultivated fish

Maximizing cost-efficiency, reducing GMP footprint and eliminating bottlenecks in lentiviral virus production: A Case Study with the Cytegrity™ Producer Cell Line in the scale-X™ Fixed-Bed Bioreactor

Tackle the challenges in GMP Lentiviral virus production processes

Production of lentiviral vector for CAR-T cell therapy development

A process transfer of lentiviral vector production with adherent HEK293T cells from a conventional system to a novel fixed-bed bioreactor

Seed train or seed culture expansion process

Wondering what it would mean to intensify your seed expansion process using the scale-X cell collect module?

Addressing scale-up challenges through technological innovation for cost-effective vaccine development

Deep dive into scaling viral manufacturing cost-effectively

Redefining extracellular vesicle production: proof of concept study evaluating structured fixed-bed bioreactor for high-capacity production

Discover how Univercells Technologies’ scale-X™ fixed-bed bioreactors achieved 2-fold increase in EV productivity enabling scalable production from proof-of-concept to large-scale continuous manufacturing

Advantages of optimized AAV harvest in fixed-bed bioreactors

The process optimization for AAV harvest contributes to high product recovery, small volumes, reduced host cell impurities and increased full/empty capsid ratio to address time and capacity gaps.

hMSC-derived extracellular vesicles in the scale-X™ hydro fixed-bed

hMSC-derived extracellular vesicles production in the scale-X™ hydro fixed-bed bioreactor

Proof-of-concept of exosomes manufacturing in scale-X™ bioreactor to demonstrate advantages of intensified and integrated platforms

Tech Transfer for AAV manufacturing- Case Study

From tech transfer to commercial scale viral manufacturing in 8 months – a CDMO case study

Innovative, scalable-by-design fixed-bed technology addresses limitations associated with stirred-tank bioreactors – Tech transfer study by CDMO Exothera

Linear and predictable scale-up in the fixed-bed bioreactor

The scale-X™ bioreactors’ design and performance features allow for linear predictability for process parameter scale-up

Improving development troubleshooting

Achieve your goal in biological processes by improving development troubleshooting, focusing on root cause analysis.

AAV manufacturing: The benefits of growing serum-free, suspension HEK293 cells in the scale-X™ fixed-bed bioreactor

Achieve 3-fold increase in AAV-2 cell-specific productivity using a suspension HEK293F cell line in the scale-X™ structured fixed-bed bioreactor

Lentivirus production study in the scale-X™ fixed-bed bioreactor

Implementation of a metabolite-based cell density estimation and evaluation of harvest strategies for Lentivirus production with HEK293T cells

AAV manufacturing: The benefits of growing serum-free, suspension HEK293 cells in the scale-X fixed-bed bioreactor

Meet capacity challenges growing a suspension HEK293 cell line in serum-free conditions to produce an AAV-2 product in high quantities with a scale-X™ fixed-bed bioreactor

Key considerations when using recirculation and perfusion processes in the scale-X™ fixed-bed bioreactor

Recirculation and perfusion are two advantageous methods for supplying medium nutrients to the cells in the scale-X™ structured fixed-bed bioreactor and for harvesting the cell-mediated product.

Addressing large scale inoculation bottlenecks by intensifying and automating the seed train

Case study for HEK293 cell harvest from fixed-bed fibers

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A proven solution to tackle gene therapy manufacturing challenges

The role of intensification and integration in rapid deployment of large viral production capacity

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Simplifying seed train: a benchtop system for intensified inoculation of large-scale bioreactors

Streamlined bioreactor-to-bioreactor seed train

How to find success with lentiviral production using fixed-bed bioreactor technology?

Highly productive lentivirus manufacture using the scale-X™ technology

Brochure

Intensified and integrated biomanufacturing technologies

Scalable and high-productivity manufacture of advanced therapies

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Scalable seed train intensification and automation for adherent cell cultures with the scale-X™ bioreactor

Achievement of large-scale, cost-efficient enzymatic cell collection from structured fixed-bed bioreactors to facilitate and de-risk seed train generation

Infographic

Reaching high capacity without large-scale bioreactors

Redefining the concepts of scale and flexibility

A Rapid Fixed-Bed Proof-of-Concept Bioreactor

Static cell cultivation and production process transferred to the scale-X™ hydro bioreactor.

Integrated continuous biomass estimation in fixed-bed bioreactors

Novel approach allows for real-time measurement of cell density in fixed-bed bioreactors

White paper

Leveraging small-scale parallel bioreactor systems for reliable and scalable processing design

Our Product Manager Clément Dumont explains how an innovative fixed-bed small-scale parallel system will revolutionize process design & optimization steps resulting in an increased production capacity & quality.

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What if you could produce most of your viral products with a single manufacturing platform?

Addressing biomanufacturing challenges through flexible platform design for both adherent & suspension cell lines