Evolving biomanufacturing technology
The NevoLine™ Upstream platform is an innovative biomanufacturing technology that delivers cost-effective viral production. This new generation platform builds on the successful NevoLine™ sIPV proof-of-concept designed to deliver affordable inactivated polio vaccine.
The high-performance, intensified platform features a flexible design to accommodate viral vaccine, gene therapy, and oncolytic virus production. With the NevoLine™ Upstream platform, automated GMP clinical and commercial-scale upstream production is achieved within a 3 m² footprint.
Applications
Viral vectors
Viral vaccines
Oncolytic viruses
Exosomes
Adherent cells
Suspension cells
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Redefining upstream virus production
The NevoLine™ Upstream platform accommodates all unit operations from inoculation to clarification and concentration within a compact module.
Pre-defined single-use assemblies can be selected and combined to meet your process requirements.
Features
Integrating the scale-X nitro bioreactor for commercial production
The scale-X nitro bioreactor enables commercial-scale production in a compact size while offering 200 m² or 600 m² surface for cell growth.
The structured fixed-bed design enables a linear scale-up from the scale-X carbo. As part of the NevoLine Upstream, the bioreactor benefits from the automation and integration offered by the platform.
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An integrated solution designed for flexibility
Benefits
High Performance
Achieving rapid commercial-scale capacity with drastically reduced operational expenditures and footprint.
Reliability
Integrating all unit steps in a compact design with automated operations for reproducible results.
Flexibility
Combining pre-defined single-use assemblies for a multitude of process designs.
Rapid deployment
Building production capacity easily in new or existing facility for rapid market access.
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Related Publications
NevoLine™ Upstream platform: integrated and automated solution for intensified virus manufacturing
The NevoLine™ Upstream system is a high-performance and automated platform for commercial virus manufacturing. It integrates all process steps from inoculation to midstream processing to deliver a ready for downstream bulk.
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What if you could produce most of your viral products with a single manufacturing platform?
Addressing biomanufacturing challenges through flexible platform design for both adherent & suspension cell lines
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Shortcut to your success
Our experienced Bioprocess & Field Services team is available to support you to quickly and efficiently start your development activities. From the installation of the equipment to process training and maintenance, they are committed to provide the support you need.